HCID 131733308, compound → HCID 29946850, compound

HRID 515884Notes

Reaction equation

HRID 515884 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C@@H:10]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][N:11]1C(OCC1C=CC=CC=1)=O)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:19][C@@H:10]([CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[NH:11]1

Participants

4

Reactant 1

HCID 131733308HCID 131733308, compound

Product 1

HCID 29946850HCID 29946850, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 21 g (53 mmol) of the compound obtained in Step D in 600 mL of ethyl acetate there are added 2.1 g of palladium-on-carbon 10%. The batch is stirred at ambient temperature under a pressure of 1.3 bars of dihydrogen for 5 hours. The reaction mixture is then filtered and then concentrated to dryness. The title product is obtained in the form of a solid.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-473aa7073d114a5bb58a04d668086f8b
Source dataset
uspto-grants-2015_08
Patent number
US09108983B2

Reaction notes

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