Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 517361Notes

Reaction equation

HRID 517361 reaction equation
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

Product 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochlorideYield 47%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The obtained N-allyl-L-aspartic acid di-tert-butyl ester was dissolved in acetonitrile (10 mL), and water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol) were added. The solution was concentrated under reduced pressure and freeze-dried to give the title compound (0.54 g, 1.7 mmol, 47%).

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. customfreeze-dried

Sources & evidence

ORD record
ord-889097096d9840028c8fd821287ab804
Source dataset
uspto-grants-2015_08
Patent number
US09115107B2

Reaction notes

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