HRID517588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCN)C2=O)cc1$

HCID1249836

未命名化合物

HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCNC)C2=O)cc1$

HCID71697257

未命名化合物

PRODUCTS

生成物

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCN(Cc3ccccc3)Cc3ccccc3)C2=O)cc1$

HCID71697350

未命名化合物

PROCEDURE

实验过程

The title compound 24b was prepared from compound 76 (117 mg, 0.40 mmol), benzaldehyde (82 μL, 0.80 mmol) and sodium triacetoxyborohydride (254 mg, 1.20 mmol) in a manner similar to that described for 23a in 93.1% (176 mg) yield as a light-yellow solid.

WORKUP

后处理

customyield as a light-yellow solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bda817e58a284208a0195c26b410c865
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09115122B2
来源说明: uspto-grants-2015_08

反应 SMILES

[NH2:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[CH:13][CH:12]=2)/[S:6][C:5]1=[O:20].[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(O[C:46]1[CH:63]=[CH:62][C:49](/[CH:50]=C2/C(=O)N(CCNC)C(=O)S/2)=[CH:48][CH:47]=1)C>>[CH2:21]([N:1]([CH2:50][C:49]1[CH:62]=[CH:63][CH:46]=[CH:47][CH:48]=1)[CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[CH:13][CH:12]=2)/[S:6][C:5]1=[O:20])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1