反应详情

To a mixture comprising 7-ethyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine (Intermediate D)(0.1 g, 0.291 mmol) in 1,2-dichloroethane (2 ml) was added molecular sieves followed by ethyl 7-oxoheptanoate (0.15 g, 0.874 mmol). The mixture was stirred for 10 minutes and treated with NaBH(OAc)3. After stirring at RT overnight, the reaction mixture was passed through Celite® (filter material) and partitioned between EtOAc and water. The organic layer was washed with saturated brine solution, dried over anhydrous sodium sulphate and concentrated under vacuum to afford the titled compound;

1. stirringAfter stirring at RT overnight
2. filtrationthe reaction mixture was passed through Celite® (filter material)
3. custompartitioned between EtOAc and water
4. washThe organic layer was washed with saturated brine solution
5. dry with materialdried over anhydrous sodium sulphate
6. concentrationconcentrated under vacuum