反应详情

温度

150 °C

To a solution of ethyl 3-bromo-6-cyano-2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (0.2 g) in 1,4-dioxane (4.0 mL) were added 2,4,6-trimethylboroxine (0.64 g), copper(I) iodide (50 mg), tripotassium phosphate (0.27 g) and tetrakis(triphenylphosphine)palladium (0.22 g), and the mixture was stirred at 150° C. for 150 minutes using microwave reactor. The reaction solution was concentrated under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=76/24−55/45) to give the title compound (0.13 g).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe obtained residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=76/24−55/45)