反应详情

温度

50 °C

To a mixed solution of ethyl 6-cyano-2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (0.64 g) in tetrahydrofuran (8.0 mL), ethanol (4.0 mL) and water (6.0 mL) was added lithium hydroxide monohydrate (1.14 g), and the mixture was stirred at 50° C. for 35 hours. The reaction solution was concentrated under reduced pressure. To the residue was added 2 mol/L hydrochloric acid (18 mL) and water. The precipitated solid was collected by filtration, washed with water, and dried under reduced pressure at 50° C. to give the title compound (0.59 g).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. additionTo the residue was added 2 mol/L hydrochloric acid (18 mL) and water
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with water
5. customdried under reduced pressure at 50° C.