反应详情

温度

170 °C

To a solution of 6-cyano-2-methyl-4H-thieno[3,2-b]pyrrole (0.37 g) in toluene (10 mL) were added methyl 4-iodo-2-(methoxymethoxy)benzoate (0.73 g), copper(I) iodide (43 mg), trans-N,N′-dimethylcyclohexanediamine (65 mg) and potassium carbonate (0.66 g), and the mixture was stirred at 170° C. for 20 minutes using microwave reactor. The reaction solution was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=78/22−57/43) to give the title compound (0.63 g).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=78/22−57/43)