HRID518369
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
The title compound of step 4 (5.00 g, 19.08 mmol), the title compound of Example 89, step 1 (5.98 g, 20.99 mmol), K3PO4 (12.13 g, 57.24 mmol), and Pd(dppf)Cl2 (1.40 g, 1.91 mmol) in dioxane/H2O (50 mL/5 mL) were N2 purged and heated at 80° C. for 8 h. Silica gel chromatography (PE: EA=10/1-1/1) to gave the title compound (5.01 g, yield: 68%) as a yellow solid. 1H NMR (CDCl3, 400 MHz) δ8.53 (s, 2H), 7.67-7.63 (m, 2H), 7.57-7.52 (m, 2H), 4.06 (d, J=6.8 Hz, 2H), 3.71 (s, 3H), 3.37 (s, 3H), 1.17 (m, 1H), 0.61 (m, 2H), 0.30 (m, 2H). LCMS: 386.1 (M+1)+
WORKUP
后处理
- custompurged