Hydrochloric Acid → HCID 178468177, compound

HRID 518630Notes

Reaction equation

HRID 518630 reaction equation
[C:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:18]>>[ClH:18].[NH2:10][C@@H:7]1[CH2:8][CH2:9][C@H:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178468181HCID 178468181, compound

Product 1

HCID 178468177HCID 178468177, compoundYield 100.3%

Procedure

A suspension of tert-butyl cis-4-acetylcyclohexylcarbamate (1.8 g, 7.46 mmol) in HCl (4M in dioxane) (93 mL, 373 mmol) was stirred at RT for 16 hours. The resulting mixture was concentrated to dryness to afford 1-(cis-4-aminocyclohexyl)ethanone hydrochloride as a white solid (1.33 g, 100% yield).

Workup

  1. concentrationThe resulting mixture was concentrated to dryness

Sources & evidence

ORD record
ord-d8c7c13a92c34c979198df7f3107fd6e
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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