Pyridine → HCID 117831258, compound

HRID 518913Notes

Reaction equation

HRID 518913 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:7][CH2:8][C:9]([OH:11])=[O:10]>C(OCC)(=O)C>[Br-:7].[C:9]([CH2:8][NH+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH2:2]1)([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 1049PyridineHCID 6227Bromoacetic Acid

Product 1

HCID 117831258HCID 117831258, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 16.2 mL of pyridine (200 mmol) in 120 mL of ethyl acetate there are added, in portions, 27.8 g (200 mmoles) of bromoacetic acid. The batch is then stirred at ambient temperature overnight. The precipitate thereby obtained is filtered off and then washed with cold ethyl acetate. After drying, the title product is obtained in the form of a powder which is used directly in the next Step.

Workup

  1. customThe precipitate thereby obtained
  2. filtrationis filtered off
  3. washwashed with cold ethyl acetate
  4. customAfter drying

Sources & evidence

ORD record
ord-afde9d84976846d382e907a97474775f
Source dataset
uspto-grants-2015_08
Patent number
US09115159B2

Reaction notes

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