Trifluoroacetic acid → HCID 86727435, compound

HRID 519069Notes

Reaction equation

HRID 519069 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6]2[CH:7]=[C:8]3[C:17](=[CH:18][C:19]=2[O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:16][CH2:15][C:14]2[N:9]3[CH:10]([CH3:28])[C:11](=[O:27])[NH:12][N:13]=2)[CH2:2]1.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[NH:1]1[CH2:2][CH:3]([NH:5][C:6]2[CH:7]=[C:8]3[C:17](=[CH:18][C:19]=2[O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:16][CH2:15][C:14]2[N:9]3[CH:10]([CH3:28])[C:11](=[O:27])[NH:12][N:13]=2)[CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86727436HCID 86727436, compound

Product 1

HCID 86727435HCID 86727435, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 6-(azetidin-3-ylamino)-4-methyl-7-phenoxy-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one (0.015 g, 0.031 mmol) in DCM (3 mL) and TFA (0.5 mL) was stirred for 2 h at ambient temperature. The solvent was removed in vacuo to give 6-(azetidin-3-ylamino)-4-methyl-7-phenoxy-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (0.009 mg, 58%) as a white solid. LC/MS (Table 1, Method 5) Rt=2.166 min; MS m/z: 380 [M+H]+

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-9d30da7960ca42cfaf7a25b55b2141b9
Source dataset
uspto-grants-2015_08
Patent number
US09115151B2

Reaction notes

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