Hydrochloric Acid → HCID 86727560, compound

HRID 519162Notes

Reaction equation

HRID 519162 reaction equation
C(OC([N:8]1[CH2:11][C:10]([N:13]([C:15]2[CH:16]=[C:17]3[C:26](=[CH:27][C:28]=2[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[O:25][CH2:24][C:23]2[N:18]3[C@H:19]([CH3:37])[C:20](=[O:36])[NH:21][N:22]=2)[CH3:14])([CH3:12])[CH2:9]1)=O)(C)(C)C.[ClH:38]>CCOC(C)=O>[ClH:38].[F:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[C:28]1[CH:27]=[C:26]2[C:17]([N:18]3[C:23]([CH2:24][O:25]2)=[N:22][NH:21][C:20](=[O:36])[C@H:19]3[CH3:37])=[CH:16][C:15]=1[N:13]([CH3:14])[C:10]1([CH3:12])[CH2:9][NH:8][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86727562HCID 86727562, compound

Product 1

HCID 86727560HCID 86727560, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-{[(R)-7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl]-methyl-amino}-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.250 g, 0.491 mmol) in EtOAc (2 mL) was added HCl (4M in EtOAc, 3 mL). The reaction mixture was stirred at ambient temperature for 30 min and then concentrated in vacuo to give (R)-7-(2-fluoro-phenyl)-4-methyl-6-[methyl-(3-methyl-azetidin-3-yl)-amino]-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one hydrochloride acid which was used directly in the next step without further purification. LC/MS (Table 1, Method 25), Rt=0.722 min., MS m/z: 410 [M+H]+

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-0d5e4c90d7034635b562bb8731129e63
Source dataset
uspto-grants-2015_08
Patent number
US09115151B2

Reaction notes

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