反应详情

温度

80 °C

16 g (43.3 mmol) of 2-(3-bromophenyl)-4,6-diphenylpyrimidine and 16.5 g (48 mmol) of 9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benz[4,5]-imidazo[2,1-a]isoquinoline are dissolved in 80 ml of toluene and degassed. 281 ml of a degassed 2M K2CO3 and 2.5 g (2.2 mmol) of Pd(OAc)2 are added. The reaction mixture is subsequently stirred at 80° C. for 48 h under protective-gas atmosphere. Additional toluene is added to the cooled solution, which is washed a number of times with water, dried and evaporated. The product is purified by column chromatography on silica gel with toluene/heptane (1:2). Ther purity is 99.9%. Yield: 19.6 g (37 mmol) 77% of theory.

1. customdegassed
2. washis washed a number of times with water
3. customdried
4. customevaporated
5. customThe product is purified by column chromatography on silica gel with toluene/heptane (1:2)