反应详情

While stirring 0.35 g of sodium hydride in 30 ml of N,N-dimethylformamide at room temperature, 1.73 g of 3-benzoyl-5-hydroxy-2-trifluoromethylbenzofuran-4-carboxylic acid was gradually added thereto. After completion of the addition, the mixture was further stirred for one hour. While stirring this mixture at room temperature, 1.08 g of 4,6-dimethoxy-2-methylsulfonylpyrimidine was added thereto, and then the mixture was stirred at 70° C. for 3 hours. The mixture was returned to room temperature and poured into water. Precipitated crystals were separated by filtration and washed with water and acetone to obtain 1.02 g (yield: 40.5%) of the desired compound.

1. additionAfter completion of the addition
2. stirringWhile stirring this mixture at room temperature
3. stirringthe mixture was stirred at 70° C. for 3 hours
4. customwas returned to room temperature
5. customPrecipitated crystals
6. customwere separated by filtration
7. washwashed with water and acetone