反应详情

温度

50 °C

To a solution of 137l (crude, 35.4 mmol) in THF/H2O (100 mL/100 mL) was added LiOH (4.26 g, 177 mmol). See FIG. 2. The mixture was stirred at 50° C. for 1 h. Upon reaction completion, the mixture was acidified with HCl (1N) until pH<6 and concentrated to remove THF. The resulting white solid was collected by filtration and washed with cold water to give 7,7-dimethyl-1-oxo-2,3,4,6,7,8-hexahydro-1H-pyrido[3,4-b]pyrrolizine-9-carboxylic acid 137m (8 g, 91%).

1. customUpon reaction completion
2. concentrationconcentrated
3. customto remove THF
4. filtrationThe resulting white solid was collected by filtration
5. washwashed with cold water