2-Bromoethyl methyl ether → 6-(2-Methoxyethylamino)-4-(3'-methylanilino)quinazoline

HRID 52037Notes

Reaction equation

HRID 52037 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=1.[CH3:20][O:21][CH2:22][CH2:23]Br>>[CH3:20][O:21][CH2:22][CH2:23][NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 10220590153436-70-5

Product 1

HCID 199631626-(2-Methoxyethylamino)-4-(3'-methylanilino)quinazolineYield 20%

Procedure

Using an analogous procedure to that described in Example 16, 6-amino-4-(3'-methylanilino)quinazoline was reacted with 2-bromoethyl methyl ether to give 6-(2-methoxyethylamino)-4-(3'-methylanilino)quinazoline in 20% yield, m.p. 163°-167° C.

Sources & evidence

ORD record
ord-ff474c5ac3884f1a91b5ea1dfd3920fe
Source dataset
uspto-grants-1997_04
Patent number
US05616582

Reaction notes

Loading…