反应详情

Tert-butyl 4-(morpholinomethyl)thiazol-2-ylcarbamate 90 (1.88 g, 6.28 mmol) was treated with 20 mL of 25% trifluoroacetic acid in CH2Cl2 for 18 h at room temperature. After all the solvent had been removed by concentrating and drying under high vacuum, the resulting residue was treated with a mixture of pentane/EtOAc to afford 91 (1.96 g, 100% yield) as a white solid.

1. customAfter all the solvent had been removed
2. concentrationby concentrating
3. customdrying under high vacuum
4. additionthe resulting residue was treated with a mixture of pentane/EtOAc