反应详情

温度

200 °C

A mixture of 2-chloro-4-aminopyridine 109 (2.29 g, 17.8 mmol) and pyrrolidine 68 (5.0 mL) was heated at 200° C. in a microwave reactor for 10 min. After cooling to room temperature, the solid was filtered and washed with dichloromethane (10 mL×3). The filter cake was dissolved in aqueous K2CO3 and extracted with CH2Cl2 (40 mL×3). The combined organic layers were dried over Na2SO4 and concentrated to obtain 110 (2.30 g, 79% yield).

1. temperatureAfter cooling to room temperature
2. filtrationthe solid was filtered
3. washwashed with dichloromethane (10 mL×3)
4. dissolutionThe filter cake was dissolved in aqueous K2CO3
5. extractionextracted with CH2Cl2 (40 mL×3)
6. dry with materialThe combined organic layers were dried over Na2SO4
7. concentrationconcentrated