反应详情

To a 1 L 3-neck flask equipped with an overhead stirrer, Claisen adaptor, nitrogen bubbler, 60 mL addition funnel, and thermocouple was added 6-(trifluoromethyl)nicotinic acid (45.0 g, 236 mmol), dichloromethane (540 mL) and DMF (0.910 mL, 11.8 mmol) via syringe. To this solution was added oxalyl chloride (24.5 mL, 283 mmol) and the reaction was allowed to stir at ambient temperature overnight. The reaction was then filtered and the clear filtrate was concentrated in vacuo to afford the title compound as a brown semisolid.

1. customTo a 1 L 3-neck flask equipped with an overhead stirrer
2. additionClaisen adaptor, nitrogen bubbler, 60 mL addition funnel
3. filtrationThe reaction was then filtered
4. concentrationthe clear filtrate was concentrated in vacuo