反应详情

温度

60 °C

To 6-bromo-2,4-dichloro-3-(4-chlorophenoxy)quinoline (0.50 g, 1.24 mmol, Intermediate 7: step c) was added N,N-dimethylformamide (3 mL) and 3-isopropoxyazetidine-HCl (0.188 g, 1.24 mmol), and the reaction was heated at 60° C. overnight. The reaction was cooled, diluted with ethyl acetate and the organic layer was washed with water five times to remove the N,N-dimethylformamide. The organic layer was dried (MgSO4), filtered and concentrated, then purified over a silica gel column with ethyl acetate/heptane to afford the title compound.

1. temperatureThe reaction was cooled
2. washthe organic layer was washed with water five times
3. customto remove the N,N-dimethylformamide
4. dry with materialThe organic layer was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified over a silica gel column with ethyl acetate/heptane