Hydrochloric Acid → HCID 86729359, compound

HRID 521194Notes

Reaction equation

HRID 521194 reaction equation
[C:1]([CH:3]=[C:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)#[N:2].[ClH:17]>O1CCOCC1>[Cl-:17].[C:1]([CH:3]=[C:4]1[CH2:9][CH2:8][NH2+:7][CH2:6][CH2:5]1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15326949tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate

Product 1

HCID 86729359HCID 86729359, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate (20 g, 90 mmol) was dissolved in 4M HCl in dioxane and allowed to stir at ambient temperature for 2 hours. The mixture was then concentrated in vacuo to afford the title compound.

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-b70ba726cde840b3a1922d722ff86ca2
Source dataset
uspto-grants-2016_05
Patent number
US09328099B2

Reaction notes

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