反应详情

温度

50 °C

2-((3-Methyl-4-(2-(4-acetylpiperazin1-yl)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole (38 g) was dissolved in 6N hydrochloric acid and the mixture was stirred at 50° C. for 2 hours. After the completion of the reaction, the mixture was made alkaline with potassium carbonate and extracted with a mixed solvent of chloroform-methanol. The chloroform-methanol layer was dried over anhydrous magnesium sulfate, the solvent was distilled away and the residue was recrystallized from ethanol to give 2-((3-methyl-4-(2-(piperazin1-yl)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole as crystals, melting point 166°-168° C.

1. customAfter the completion of the reaction
2. extractionextracted with a mixed solvent of chloroform-methanol
3. dry with materialThe chloroform-methanol layer was dried over anhydrous magnesium sulfate
4. distillationthe solvent was distilled away
5. customthe residue was recrystallized from ethanol