反应详情

2-((3-Methyl-4-(2-benzylaminoethylthio)pyridin-2-yl)methylthio)-1H-benzimidazole (2 g) was dissolved in dimethylformamide and reacted with methyl chloroacetate (0.45 ml) in the presence of potassium carbonate (0.71 g) at 50°-60° C. After the completion of the reaction, the dimethylformamide was distilled away and the residue was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and the solvent was distilled away to give an oily product. The oily product was purified by column chromatography to give 2-((3-methyl-4-(2-(N-benzyl-N-methoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole.

1. customAfter the completion of the reaction
2. distillationthe dimethylformamide was distilled away
3. extractionthe residue was extracted with ethyl acetate
4. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled away
6. customto give an oily product
7. customThe oily product was purified by column chromatography