Hydrochloric Acid → HCID 73603937, compound

HRID 521739Notes

Reaction equation

HRID 521739 reaction equation
[NH2:1][C:2]1[S:3][CH2:4][C@@H:5]2[CH2:10][N:9]([C:11]3[N:16]=[C:15]([C:17]([OH:20])([CH3:19])[CH3:18])[C:14]([F:21])=[CH:13][N:12]=3)[CH2:8][C@:6]2([C:22]2[CH:27]=[N:26][CH:25]=[CH:24][N:23]=2)[N:7]=1.[ClH:28]>C(#N)C>[ClH:28].[NH2:1][C:2]1[S:3][CH2:4][C@@H:5]2[CH2:10][N:9]([C:11]3[N:16]=[C:15]([C:17]([OH:20])([CH3:18])[CH3:19])[C:14]([F:21])=[CH:13][N:12]=3)[CH2:8][C@:6]2([C:22]2[CH:27]=[N:26][CH:25]=[CH:24][N:23]=2)[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73603938HCID 73603938, compound

Product 1

HCID 73603937HCID 73603937, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-[2-[(4aR,7aR)-2-amino-7a-pyrazin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-6-yl]-5-fluoro-pyrimidin-4-yl]propan-2-ol (120 mg, 0.308 mmol) is dissolved in 0.1 M HCl (3.1 mL) and acetonitrile (1 mL). The resulting solution is freeze dried to obtain the title compound as a white solid. ES/MS (m/e): 390 (M+1).

Workup

  1. customdried

Sources & evidence

ORD record
ord-1b851fd48198424db33a3927a15df3fb
Source dataset
uspto-grants-2016_05
Patent number
US09328124B2

Reaction notes

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