Diisopropylethylamine → HCID 67042298, compound

HRID 521804Notes

Reaction equation

HRID 521804 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]([NH:12][C:13]1[CH:33]=[CH:32][C:16]([O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([C:24]3[CH:25]=[C:26]([C:29](O)=[O:30])[NH:27][CH:28]=3)[CH:19]=2)=[CH:15][CH:14]=1)=[O:11].[CH3:34][N:35](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN.C1COCC1.C(N(CC)C(C)C)(C)C>CN(C=O)C.O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]([NH:12][C:13]1[CH:33]=[CH:32][C:16]([O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([C:24]3[CH:25]=[C:26]([C:29]([NH:35][CH3:34])=[O:30])[NH:27][CH:28]=3)[CH:19]=2)=[CH:15][CH:14]=1)=[O:11]

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 66615946Methylamine tetrahydrofuranHCID 67042509HCID 67042509, compound

Product 1

HCID 67042298HCID 67042298, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid (50 mg, 0.11 mmol), HATU (50 mg, 0.13 mmol), 2M methylamine/THF solution (0.1 ml, 0.2 mmol) and N,N-diisopropylethylamine (31 mg, 0.24 mmol) in anhydrous DMF (8 ml) was stirred at room temperature for 10 minutes. The mixture was poured into 100 ml of water. The precipitates were filtered, washed with water and dried to give the crude, which was purified by silica gel chromatography with 3˜5% MeOH/CHCl3 to give 4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-N-methyl-1H-pyrrole-2-carboxamide as white solid. Yield: 21 mg, 41%.

Workup

  1. filtrationThe precipitates were filtered
  2. washwashed with water
  3. customdried
  4. customto give the crude, which
  5. customwas purified by silica gel chromatography with 3˜5% MeOH/CHCl3

Sources & evidence

ORD record
ord-2c772ccc2db7477b838ccf13043951df
Source dataset
uspto-grants-2016_05
Patent number
US09328103B2

Reaction notes

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