Trifluoroacetic acid → Trifluoroacetic acid

HRID 522202Notes

Reaction equation

HRID 522202 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([S:24]([C:27]3[CH:33]=[CH:32][C:30]([CH3:31])=[CH:29][CH:28]=3)(=[O:26])=[O:25])[C:9]([C:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH:12]=3)=[CH:10][C:3]=12.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([S:24]([C:27]3[CH:28]=[CH:29][C:30]([CH3:31])=[CH:32][CH:33]=3)(=[O:26])=[O:25])[C:9]([C:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH:12]=3)=[CH:10][C:3]=12.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90409204HCID 90409204, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 90411970HCID 90411970, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of Example 5C (8 g, 15.02 mmol) and trifluoroacetic acid (11.58 mL, 150 mmol) in dichloromethane (100 mL) was stirred at 20° C. for 12 hours and the mixture was concentrated to provide the title compound as a trifluoroacetic acid salt. MS (CI) m/z 432 (M+H)+.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-a01ba4491c5346c8b58912ca6b9899d3
Source dataset
uspto-grants-2016_05
Patent number
US09328112B2

Reaction notes

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