Trifluoroacetic acid → HCID 118274116, compound

HRID 522222Notes

Reaction equation

HRID 522222 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([CH3:15])[CH2:13][C:12]3[C:8]4[C:9](=[N:32][CH:33]=[CH:34][C:7]=4[C:6]=2[CH:35]=1)[NH:10][C:11]=3[C:16]1[CH2:17][CH:18]2[N:24](C(OC(C)(C)C)=O)[CH:22]([CH:23]=1)[CH2:21][CH2:20][CH2:19]2.FC(F)(F)C(O)=O>ClCCl>[CH:18]12[NH:24][CH:22]([CH2:21][CH2:20][CH2:19]1)[CH:23]=[C:16]([C:11]1[NH:10][C:9]3[C:8]4[C:12]=1[CH2:13][N:14]([CH3:15])[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:35][C:6]=1[C:7]=4[CH:34]=[CH:33][N:32]=3)[CH2:17]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118274223HCID 118274223, compound

Product 1

HCID 118274116HCID 118274116, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 99C (1.135 g, 2.392 mmol) in dichloromethane (6 mL) was treated with trifluoroacetic acid (3 mL) at room temperature for 30 minutes, and concentrated in vacuo. The crude product (LC-MS 375.2 (M+H)+) was directly used for next step.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7c1edbee70894ebdac867a631e4eb192
Source dataset
uspto-grants-2016_05
Patent number
US09328112B2

Reaction notes

Loading…