Hydrochloric Acid → HCID 117598905, compound

HRID 522350Notes

Reaction equation

HRID 522350 reaction equation
[CH:1]([C@@H:3]1[CH2:5][C@:4]1([NH:18]C(=O)OC(C)(C)C)[C:6](=[O:17])[NH:7][S:8]([C:11]1([C:14]([CH3:16])=[CH2:15])[CH2:13][CH2:12]1)(=[O:10])=[O:9])=[CH2:2].[ClH:26]>O1CCOCC1>[ClH:26].[NH2:18][C@:4]1([C:6]([NH:7][S:8]([C:11]2([C:14]([CH3:16])=[CH2:15])[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[O:17])[CH2:5][C@H:3]1[CH:1]=[CH2:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131735529HCID 131735529, compound

Product 1

HCID 117598905HCID 117598905, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of step 1 (136 mg) was dissolved in a solution of HCl in dioxane (1.5 mL). The mixture was stirred for 3 hours at room temperature. The solvent was removed in vacuo and the crude product was used in the next step. 1H NMR (400 MHz, CDCl3): δ (ppm) 5.69-5.62 (m, 1H), 5.41 (d, 1H), 5.26 (d, 1H), 5.23 (s, 1H), 5.21 (s, 1H), 2.77-2.72 (m, 1H), 2.02-1.98 (m, 1H), 1.95 (s, 3H), 1.93-1.84 (m, 2H), 1.74-1.69 (m, 1H), 1.17-1.06 (m, 2H).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-a4559755634c46c1b8bc1497f14ceb01
Source dataset
uspto-grants-2016_05
Patent number
US09328138B2

Reaction notes

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