反应详情

The product of Step 1 (16.63 g) was dissolved in THF (150 mL) and 2N NaOH (145 mL) was added over 15 minutes. The reaction was stirred for 24 hours. The reaction mixture was concentrated to remove the THF. Diethyl ether (20 mL) was added and the layers were separated. The aqueous layer was acidified to pH=2.2 with 1N HCl which resulted in the precipitation of solids. Ethyl acetate was added until the solids were dissolved and the layers were separated. The organic extract was dried with sodium sulfate, filtered and concentrated to give 14.7 g of a cake.

1. concentrationThe reaction mixture was concentrated
2. customto remove the THF
3. additionDiethyl ether (20 mL) was added
4. customthe layers were separated
5. customresulted in the precipitation of solids
6. dissolutionwere dissolved
7. customthe layers were separated
8. extractionThe organic extract
9. dry with materialwas dried with sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated
12. customto give 14.7 g of a cake