反应详情

温度

100 °C

Treat a solution of 2-fluoro-4-methyl-5-(7-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-6-yl)benzenamine (0.300 g, 0.954 mmol) in DMF (1 mL) with 2-methoxyethanamine (0.430 g, 5.73 mmol) in a screw-capped vial and heat at 100° C. for 20 h. Cool the mixture to RT, treat with H2O and extract with EtOAc (2×). Wash the combined organics with brine, dry over Na2SO4 and concentrate to dryness to afford the title compound as a dark semi-solid (278 mg, 85% yield). MS (m/z): 342.2 (M+1).

1. temperatureCool the mixture to RT
2. extractionextract with EtOAc (2×)
3. washWash the combined organics with brine
4. dry with materialdry over Na2SO4
5. concentrationconcentrate to dryness