反应详情

To a microwave vial charged 3-(4-(3-hydroxypropylamino)-1,3,5-triazin-2-ylamino)-N-methylbenzamide (0.112 g, 0.370 mmol) was added dichloroethane (4 mL), triphenylphosphine (0.146 g, 0.556 mmol), p-chlorophenol (0.095 g, 0.741 mmol)) and DEAD (0.129 g, 0.741 mmol) respectively. The reaction mixture was irradiated in the microwave at 130° C. for 30 min. The reaction mixture was concentrated under reduced pressure and purified with flash chromatography using CH2Cl2:MeOH:NH4OH (90:10:1) in CH2Cl2 to afford 3-(4-(3-(4-chlorophenoxy)propylamino)-1,3,5-triazin-2-ylamino)-N-methylbenzamide (30 mg, 20%) as a white solid.

1. customThe reaction mixture was irradiated in the microwave at 130° C. for 30 min
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. custompurified with flash chromatography