反应详情

To 2-bromo-6-fluoropyridine (150.0 mg, 0.852 mmol) in 2-propanol (3.00 mL) at RT was added N-ethyl-N-isopropylpropan-2-amine (0.445 mL, 2.56 mmol) followed by 3-(4-fluorophenoxy)azetidine hydrochloride (174 mg, 0.852 mmol). The resulting reaction mixture was stirred at RT for 3.5 h, then heated to 70° C. for 24 h, cooled to RT and concentrated. Purification of the crude product using MPLC (5 g cartridge, 12 g column, 0 to 60% EtOAc-hexanes) gave 2-bromo-6-(3-(4-fluorophenoxy)azetidin-1-yl)pyridine (211.4 mg).

1. customThe resulting reaction mixture
2. temperatureheated to 70° C. for 24 h
3. temperaturecooled to RT
4. concentrationconcentrated
5. customPurification of the crude product