反应详情

温度

120 °C

To a solution of tert-butyl 3-(tosyloxy)azetidine-1-carboxylate (1.0 g, 3.05 mmol) and 2,4-dichlorophenol (0.490 g, 3.05 mmol) in DMF (10 mL) was added potassium carbonate (0.630 g, 4.67 mmol) and the reaction mixture was heated to 120° C. for 2 h. Then reaction was quenched with water and extracted with EtOAc (2×25 mL). The organic extracts were washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography provided tert-butyl 3-(2,4-dichlorophenoxy)azetidine-1-carboxylate (1.2 g, 63%) as a solid.

1. customThen reaction
2. customwas quenched with water
3. extractionextracted with EtOAc (2×25 mL)
4. washThe organic extracts were washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customPurification by silica gel column chromatography