反应详情

To a solution of 3-aminopropan-1-ol (1.0 g, 13.1 mmol) and isobenzofuran-1,3-dione (2.0 g, 13.1 mmol) in toluene (25 mL, 3 mL/mmol) was added Et3N (2 mL, 13.1 mmol) and the reaction was heated at reflux for 24 h. Then reaction was quenched with water and extracted with EtOAc (2×40 mL). The organic extracts were washed with brine, dried over sodium sulfate and concentrated under reduced pressure to afford 2-(3-hydroxypropyl)isoindoline-1,3-dione (1.8 g, 87%). Observed mass (M+1): 206.1. This material was taken to the next step without further purification.

1. temperaturethe reaction was heated
2. temperatureat reflux for 24 h
3. customThen reaction
4. customwas quenched with water
5. extractionextracted with EtOAc (2×40 mL)
6. washThe organic extracts were washed with brine
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated under reduced pressure