Methanol → HCID 118676249, compound

HRID 523041Notes

Reaction equation

HRID 523041 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[O:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].[CH3:17]O>>[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH:5][CH:11]([O:10][CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

4

Reactant 3

HCID 887MethanolHCID 70211Ethyl oxoacetateHCID 774693,4-Difluoroaniline

Product 1

HCID 118676249HCID 118676249, compound

Procedure

To a stirred solution of 2.0 g (15 mmol) of 3,4-difluoroaniline in methanol is added 4.0 g (39 mmol) of ethyl 2-oxoacetate. After stirring for 14 h, the mixture is concentrated to provide 3.7 g of I-03a that is used directly without purification.

Workup

  1. concentrationthe mixture is concentrated
  2. customto provide 3.7 g of I-03a that
  3. customis used directly without purification

Sources & evidence

ORD record
ord-addf927a9751466e910a8425d896bb2a
Source dataset
uspto-grants-2016_05
Patent number
US09334285B2

Reaction notes

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