反应详情

Potassium carbonate (9 mg, 0.0654 mmol) was added to a solution of 3-chloro-6-((trimethylsilyl)ethynyl)isoquinoline (Preparation 51, 170 mg, 0.654 mmol) in methanol (1 mL) and the reaction was stirred for 1 hour. Ethyl acetate (20 mL) was added and the organic solution was washed with water (20 mL), brine (20 mL), dried over sodium sulphate and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with 50% hexane in dichloromethane to afford the title compound as a white powder (110 mg, 90%).

1. washthe organic solution was washed with water (20 mL), brine (20 mL)
2. dry with materialdried over sodium sulphate
3. concentrationconcentrated in vacuo
4. customThe residue was purified by silica gel column chromatography
5. washeluting with 50% hexane in dichloromethane