Potassium Carbonate → HCID 136490486, compound

HRID 523112Notes

Reaction equation

HRID 523112 reaction equation
C([O-])([O-])=O.[K+].[K+].[Br:7][C:8]1[N:12]([CH3:13])[C:11]([CH:14]=O)=[N:10][CH:9]=1.Cl.[NH2:17][OH:18]>CCO>[Br:7][C:8]1[N:12]([CH3:13])[C:11](/[CH:14]=[N:17]/[OH:18])=[N:10][CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 127422765-Bromo-1-methyl-1H-imidazole-2-carbaldehyde

Product 1

HCID 136490486HCID 136490486, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of K2CO3 (360 mg, 2.61 mmol), 5-bromo-1-methyl-1H-imidazole-2-carbaldehyde (98.5 mg, 0.521 mmol) and hydroxylamine hydrochloride (109 mg, 1.563 mmol) in EtOH (4 mL) was stirred at 120° C. under microwave irradiation for 60 minutes. The resulting suspension was filtered, washing through with EtOAc and MeOH. The filtrate was concentrated in vacuo to afford the title compound as a white solid (100 mg, 94%).

Workup

  1. filtrationThe resulting suspension was filtered
  2. washwashing through with EtOAc and MeOH
  3. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-acdfc5d1972549439333ae12d69fbe9d
Source dataset
uspto-grants-2016_05
Patent number
US09334286B2

Reaction notes

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