反应详情

286 mg (1.49 mmol) of 4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-amine were dissolved in THF, 0.52 ml of triethylamine was added, and 263 mg of trifluoropropionyl chloride were added while cooling with an ice bath. The mixture was stirred at room temperature overnight and then concentrated. Ethyl acetate, saturated sodium chloride solution and aqueous phosphate buffer pH=7 were added to the residue, the aqueous phase was extracted twice with ethyl acetate, and the combined organic phases were dried over Na2SO4 and concentrated. The residue was purified by chromatography (silica gel, cyclohexane, acetone).

1. temperaturewhile cooling with an ice bath
2. concentrationconcentrated
3. additionEthyl acetate, saturated sodium chloride solution and aqueous phosphate buffer pH=7 were added to the residue
4. extractionthe aqueous phase was extracted twice with ethyl acetate
5. dry with materialthe combined organic phases were dried over Na2SO4
6. concentrationconcentrated
7. customThe residue was purified by chromatography (silica gel, cyclohexane, acetone)