Triethylamine → HCID 136268344, compound

HRID 523489Notes

Reaction equation

HRID 523489 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:29])[CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(N(CC)CC)C>C(O)CC(C)C.C(#N)C>[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:29])[CH2:22][N:23]1[CH2:24][CH2:25][N:26]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[N:4]=2)[CH2:27][CH2:28]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 2737189N-2-Pyridinyl-1-piperazineacetamideHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268344HCID 136268344, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol), N-(2-pyridyl)-2-(piperazin-1-yl)acetamide * 3HCl * 2H2O (279.5 mg; 0.76 mmol) and triethylamine (282.5 μl; 2.04 mmol) are reacted in isoamyl alcohol (2 ml) in accordance with the procedure for Example 9 (reaction time 8 h) and worked up. The crystals obtained are dissolved in acetonitrile and water and freeze-dried; yield: 19 mg (10%), crystals;

Workup

  1. customThe crystals obtained
  2. dry with materialwater and freeze-dried

Sources & evidence

ORD record
ord-423554601b334d4dba76f3d9d59ff9e8
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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