Triethylamine → HCID 136268339, compound

HRID 523493Notes

Reaction equation

HRID 523493 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[F:14][C:15]([F:23])([F:22])[CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C(N(CC)CC)C>C(O)CC(C)C>[F:14][C:15]([F:23])([F:22])[CH:16]1[CH2:21][CH2:20][N:19]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[N:4]=2)[CH2:18][CH2:17]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1364694-(Trifluoromethyl)piperidineHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268339HCID 136268339, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol), 4-trifluoromethylpiperidine * HCl (97 mg; 0.51 mmol) and triethylamine (141.3 μl; 1.02 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1 (reaction time 4 h) and worked up. The crude product obtained in this way is purified by column chromatography; yield: 43 mg (28%), crystals;

Sources & evidence

ORD record
ord-2609cda6dc534e3cb34f2a94fb691e1e
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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