反应详情

A solution of 3-iodo-4-Hydroxybenzoic acid (7.25 g, 27.4 mmol) and sulfuric acid (1.9 ml, 36 mmol) in methanol is stirred at 55° C. for 6 hours. TLC (dichloromethane): 30% of starting material. The solution is stirred 12 h at room temperature. TLC (dichloromethane): 10% of starting material and stirred at 55° C. for 2 h. After cooling, ethyl acetate (200 mL) was added and the mixture was adjusted to pH 3 using sodium bicarbonate. The organic layer was washed two times with water and then dried over MgSO4. Filtration and rotary evaporation at 40° C. afforded a white solid. The solid was triturated with hexane, filtered off and dried under reduced pressure. M=4.47 g. Yield: 59%.

1. temperatureAfter cooling
2. washThe organic layer was washed two times with water
3. dry with materialdried over MgSO4
4. filtrationFiltration and rotary evaporation at 40° C.
5. customafforded a white solid
6. customThe solid was triturated with hexane
7. filtrationfiltered off
8. customdried under reduced pressure