Phosphoric Acid → Isobutylidene diurea

HRID 523850Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[O:3].S(=O)(=O)(O)O.P(=O)(O)(O)O.[CH:15](=O)[CH:16]([CH3:18])[CH3:17]>>[CH:15]([NH:1][C:2]([NH2:4])=[O:3])([NH:1][C:2]([NH2:4])=[O:3])[CH:16]([CH3:18])[CH3:17]

Participants

Reactant 4

HCID 1004Phosphoric Acid

HCID 1118Sulfuric Acid

HCID 1176Urea

HCID 6561Isobutyraldehyde

Product 1

HCID 22478Isobutylidene diurea

Conditions

Temperature: 40 °C

Procedure

The urea solution was added to the reactor followed by requisite amount of sulfuric acid and phosphoric acid. The mixture was then stirred and heated up to 40° C. The liquid isobutyraldehyde was then added slowly through the dropping funnel and no exotherm was observed and reaction was not initiated. The reaction was run at the same temperature for 30 minutes, but the white solid isobutylidene diurea product was not formed. The GC analysis did not show any significant conversion of isobutyraldehyde. Consequently, the unreacted isobutyraldehyde was ˜100%.

Workup

customreaction

Sources & evidence

ORD record: ord-b2a1f9275588460b9f3679544168cec2
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340495B2

Reaction notes

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