Nitromethane → AGN-PC-0JSX8C

HRID 523989Notes

Reaction equation

HRID 523989 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([O:17][CH3:18])=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:19]([CH3:22])([O-:21])=[O:20].C([O-])(=O)C.[NH4+]>CC(O)=O>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:11]([CH:12]=[CH:22][N+:19]([O-:21])=[O:20])[C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6375NitromethaneHCID 517165Ammonium AcetateHCID 154443393-(Benzyloxy)-2-methoxybenzaldehyde

Product 1

HCID 561829AGN-PC-0JSX8C

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4.46 g (18.4 mmol) 3-Benzyloxy-2-methoxy-benzaldehyde (see CN 102451178), 2.96 mL (55.2 mmol) nitromethane and 1.42 g (18.4 mmol) ammonium acetate in 30 mL AcOH are stirred at 100° C. over night. The reaction mixture is cooled to r.t. and quenched by the addition of 20 mL MeOH and 6 mL water. After stirring at r.t. for 1 h, the precipitate is filtered off and dried at 40° C.

Workup

  1. customquenched by the addition of 20 mL MeOH and 6 mL water
  2. filtrationthe precipitate is filtered off
  3. customdried at 40° C.

Sources & evidence

ORD record
ord-d208c066d7f6420692c9f0dd5fb83d98
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

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