HCID 118939106, compound → HCID 117998818, compound

HRID 524010Notes

Reaction equation

HRID 524010 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:17][CH:16]([OH:18])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:19]CC3C=CC=CC=3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:17][CH:16]([OH:18])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:19])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 118939106HCID 118939106, compound

Product 1

HCID 117998818HCID 117998818, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

6.0 g (17 mmol) 6-Benzyloxy-4-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (example XL) in 80 mL THF are hydrogenated (3 bar, r.t.) using 200 mg Pd/C (10%). The reaction mixture is filtered and the solvent is removed in vacuo.

Workup

  1. custom(3 bar, r.t.)
  2. filtrationThe reaction mixture is filtered
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-f1e4ae50eda14553a296d84c2d499f88
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

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