Hydrochloric Acid → HCID 118939129, compound

HRID 524014Notes

Reaction equation

HRID 524014 reaction equation
C(OC([N:8]1[CH2:17][CH:16]([O:18][CH3:19])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:20][CH2:21][CH:22]3[CH2:24][CH2:23]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH:22]1([CH2:21][O:20][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:17][CH:16]3[O:18][CH3:19])[CH2:23][CH2:24]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118939124HCID 118939124, compound

Product 1

HCID 118939129HCID 118939129, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To 200 mg (0.600 mmol) 6-cyclopropylmethoxy-4-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (example XLVI) in 3 mL dioxane are added 600 μL (2.40 mmol) HCl solution in dioxane (c=4 mol/L). After stirring over night at r.t. the reaction mixture is treated with DIPE, the precipitate is filtered off and dried at 40° C.

Workup

  1. additionis treated with DIPE
  2. filtrationthe precipitate is filtered off
  3. customdried at 40° C.

Sources & evidence

ORD record
ord-ec3639f8022649ce980a0a6116019148
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

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