反应详情

温度

25 °C

To ethyl 2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetate (0.6 g, 1.51 mmol) was added a solution of lithium hydroxide (0.317 g, 7.22 mmol) in water (4 mL) followed by THF (4 mL) and methanol (0.5 mL) and stirred for 12 hours at 25° C. Organic solvents were evaporated from the reaction mixture and aqueous layer was acidified 1N HCl, extracted with ethyl acetate (3×15 mL), organic layer was washed with brine solution, dried over anhydrous sodium sulfate, and washed concentrated under reduced pressure to provide 2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetic acid (0.5 g).

1. customOrganic solvents were evaporated from the reaction mixture and aqueous layer
2. extractionextracted with ethyl acetate (3×15 mL), organic layer
3. washwas washed with brine solution
4. dry with materialdried over anhydrous sodium sulfate
5. washwashed
6. concentrationconcentrated under reduced pressure