反应详情

温度

25 °C

To (4-cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid ethyl ester (23.2 g, 62.87 mmol) was added a solution of lithium hydroxide (13.0 g, 314.36 mmol) in water (150 mL) followed by THF (200 mL) and methanol (10 mL) and stirred for 2 hours at 25° C. Organic solvents were evaporated from the reaction mixture and aqueous layer was acidified 1N HCl, extracted with ethyl acetate (3×200 mL), organic layer was washed with brine solution, dried over anhydrous sodium sulfate, and washed concentrated under reduced pressure to provide (4-cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid (18.49 g)

1. customOrganic solvents were evaporated from the reaction mixture and aqueous layer
2. extractionextracted with ethyl acetate (3×200 mL), organic layer
3. washwas washed with brine solution
4. dry with materialdried over anhydrous sodium sulfate
5. washwashed
6. concentrationconcentrated under reduced pressure