Lithium Hydroxide → HCID 86669559, compound

HRID 524437Notes

Reaction equation

HRID 524437 reaction equation
C[O:2][C:3](=[O:41])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C:11]2[S:15][C:14]([NH:16][C:17](=[O:40])[CH:18]([C:26]3[CH:27]=[N:28][C:29]([S:32]([CH:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)(=[O:34])=[O:33])=[CH:30][CH:31]=3)[O:19][CH:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[N:13][CH:12]=2)[CH:5]=1.[Li+].[OH-]>O.C1COCC1.CO>[CH:35]1([S:32]([C:29]2[N:28]=[CH:27][C:26]([CH:18]([O:19][CH:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[C:17]([NH:16][C:14]3[S:15][C:11]([O:10][C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:41])=[O:2])=[CH:12][N:13]=3)=[O:40])=[CH:31][CH:30]=2)(=[O:33])=[O:34])[CH2:36][CH2:37][CH2:38][CH2:39]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86669557HCID 86669557, compound

Product 1

HCID 86669559HCID 86669559, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

The compound of example B8 was obtained by similar method described in example B1 using 3-[2-[[2-(6-cyclopentylsulfonyl-3-pyridyl)-2-tetrahydropyran-4-yloxy-acetyl]amino]thiazol-5-yl]oxybenzoic acid methyl ester (Example A10; 0.140 g, 0.232 mmol), LiOH (0.049 g, 1.16 mmol) in Water:THF:MeOH (2:1:0.2 8 mL) to provide the title compound (0.100 g).

Sources & evidence

ORD record
ord-7cac5e32f5d947208f46a64751920651
Source dataset
uspto-grants-2016_05
Patent number
US09340506B2

Reaction notes

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