反应详情

95.6 mg (0.23 mmol) of ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-1-benzyl-6-quinolinyl)ethynyl]benzoate (Compound 37) in 2 ml of THF, 2 ml of EtOH, and 1 ml of 1N LiOH were reacted substantially in accordance with the procedure used for the preparation of 4-[4,4-dimethyl-2-isopropoxy-1,2,3,4-tetrahydro-6-quinolinyl]ethynyl benzoic acid (Compound 11) to give the title compound as a white solid (131 mg).