Hydrochloric Acid → 3-Morpholin-3-yl-propionic acid hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=O)(C)(C)C.[ClH:19]>CCOC(C)=O>[ClH:19].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[CH2:14][CH2:15][C:16]([OH:18])=[O:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
To a solution of 3-(4-(tert-butoxycarbonyl)morpholin-3-yl)propanoic acid (0.3 g, 1.2 mmol) in EtOAc (2 mL) was added the solution of HCl in EtOAc (6 mol/L, 6 mL). The mixture was stirred closedly at 25° C. for 2 hours and filtered. The residue was washed with EtOAc (4 mL) to give the title compound as a white solid (0.21 g, 90%). The compound was characterized by the following spectroscopic data:
Workup
- filtrationfiltered
- washThe residue was washed with EtOAc (4 mL)
Sources & evidence
- ORD record
- ord-115f5f3c27054f1f957714721490271c
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09340538B2
Reaction notes
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